Menthol is an organic compound, more specifically a monoterpenoid, made synthetically or obtained from the oils of corn mint, peppermint, or other mints. It is a waxy, clear or white crystalline substance, which is solid at room temperature and melts slightly above. Peppermint oil. Bethesda MD: National Center for Complementary and Alternative Medicine; 2016 [accessed Nov 16, 2017]. Poison Post June 2014. Essential oils: poisonous when misused. Poison Post; Jun 2014. Lastly, some researchers think that cigarettes with menthol might increase the risk of becoming addicted to smoking and might be more toxic than regular cigarettes. Nicotine replacement products used to stop smoking work for menthol cigarette smokers as well.

Menthol in Skin Wound Healing—Anti-Inflammatory The Use of Menthol in Skin Wound Healing—Anti-Inflammatory

Essential oils are derived from plants. Their purpose is not exactly known, but some experts think that it could be a protective mechanism for the plant; others propose that they might attract pollinators. Peppermint is a popular essential oil used alone and in combination with other essential oils. Menthol is the main component of peppermint oil and is responsible for the noticeable cooling sensation. Menthol is extracted from plants or synthesized and can be found in throat lozenges, intranasal inhalers, lotions, pain creams, foods, and many other products. A macro photograph of menthol crystals Menthol crystals at room temperature. Approx. 1cm in length. James A. Duke (2002), "PEPPERMINT", Handbook of Medicinal Herbs (2nded.), pp.562–564, ISBN 978-0-8493-1284-7 The estimated lethal dose for menthol (and peppermint oil) in humans may be as low as 50–500mg/kg, (LD50 Acute: 3300mg/kg [Rat]. 3400mg/kg [Mouse]. 800mg/kg [Cat]).Cold, cough, allergy, bronchodilator, and antiasthmatic drug products for over-the-counter human use; amendment of final monograph for OTC antitussive drug products. Fed Regist 2000;65:46864-8. The animal study was reviewed and approved by the Commission on the Ethics of Scientific Research, Faculty of Pharmacy, Minia University (Approval Number: ES02/2020). Author Contributions

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The application of menthol to cutaneous tissue and submucosal tissue is common in clinical practice for the alleviation of pain and to promote a cooling effect ( 54). However, there is increasing interest in the potential for menthol to exert anti-inflammatory effects when applied to the skin and associated tissues, including inflammation associated with pathological conditions and processes. Andersen et al. ( 39) reported that the application of a 40% menthol-based cream to an area of irritation and inflammation on the forearm leads to a reduction in pain, neurogenic inflammation, and hyperalgesia (high responsiveness to sensations). This study utilized topical 10% trans-cinnamaldehyde application to elicit the cutaneous symptoms, with the treatment of menthol simultaneously noted to reduce pain intensity (P<0.01), neurogenic inflammation (P<0.01), and hyperalgesia (P<0.05) compared with symptoms when menthol was not applied. Results: The decrease in pro-inflammatory cytokines and related inflammatory markers, as well as associated pathway activation, was found to play the greatest role in the protective effects of menthol against inflammatory damage or association with protection against chronic inflammation. The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Abbreviations of Clinical Pharmacy and Pharmacology, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia

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The bronchoalveolar lavage fluid (BALF) was obtained by washing the airways three times with 0.5 ml of saline using a tracheal cannula ( 37). The BALF was used for the determination of total protein and WBC count. Briefly, after centrifugation (1,000 rpm, 10 min at 4°C) of the BALF, the cell pellet was resuspended in 0.5 ml PBS and the total cells were counted using a hemocytometer. Total protein was measured in the supernatant of the BALF based on its reaction with copper ions that produces a blue-violet color proportional to the concentration of the protein in the sample using a commercial kit (BioMed, Egypt). Assessment of Serum Creatinine Eccles, R. (1994). "Menthol and Related Cooling Compounds". J. Pharm. Pharmacol. 46 (8): 618–630. doi: 10.1111/j.2042-7158.1994.tb03871.x. PMID 7529306. S2CID 20568911.

Menthol - Wikipedia Menthol - Wikipedia

Balsam tissues in regular are my favourites, as they are strong and the box is not too big, so I can put it nearly anywhere in the house. Moreover, the total protein content and the total number of WBCs were significantly higher in the BALF collected from septic rats if compared with sham groups, while the treatment of CLP animals with menthol resulted a significant ( p< 0.05) reduction of both total protein and the count of blood cells in collected BALF ( Figures 2C,D). Protective Effect of Menthol on Sepsis-Induced Acute Kidney Injury Hawthorn M, Ferrante J, Luchowski E, Rutledge A, Wei XY, Triggle DJ (April 1988). "The actions of peppermint oil and menthol on calcium channel dependent processes in intestinal, neuronal and cardiac preparations". Alimentary Pharmacology & Therapeutics. 2 (2): 101–18. doi: 10.1111/j.1365-2036.1988.tb00677.x. PMID 2856502. S2CID 24596984. The story of the lip balm is not an entire family friendly one. Let us just say that I suddenly had to distract DS, so I showed him "the little tin" as we came to call it. DS was so amazed by it, I and DH and were so embarrassed at the time that we could not find the lip balm again for another day. DH finally found it in one of DS's bags, and I moved it into my work hand bag.

Effect of TRP channels on the anti-inflammatory effect of menthol

Balm ones in the kitchen for everyone to use - they were even used for light dusting by ds2. Came in very handy last night when I was watching obem and sobbing a bit. GSH concentration was measured colorimetrically according to the method described by Rifai ( 43). The activity of SOD was determined according to a previously described method ( 44) using a commercially available kit (Biodiagnostic, Egypt). Immunohistochemical Assessment of Lung and Kidney Caspase-3, Bcl-2, Proliferating Cell Nuclear Antigen, and TNF-α The big size box in the car (came handy at a funeral), a box in the living room and the balm ones are in the bathroom. Oppenheim, A. (1861). "Note sur le camphre de menthe"[On the camphor of mint]. Comptes Rendus. 53: 379–380. Les analogies avec le bornéol me permettent de proposer pour ce corps le nom de menthol,… [Analogies with borneol allow me to propose the name menthol for this substance,…]